Badania kliniczne

MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunombicin.

Abstract: Background: MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi..

Modified Arabinoxylan Rice Bran (MGN-3/BioBran) enhances Intracellular killing of microbes by human Phagocytic cells In Vitro

Abstract: Phagocytic cells, comprised of neutrophils and moncytyes/macrophages, play a key role in the innate immune response to infection. Our earlier study demonstrated that arabinoxylan rice bran (MGN-3/Biobran) activates murine peritoneal macrophage and macrophage cell lines…

Yeast therapy for the treatment of cancer and its enhancement by MGN-3/BioBran, an Arabinoxylan rice bran

Abstract: Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative…

In Vivo Tumor lnhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice.

Abstract: This study was undertaken to investigate the in vivo anti-tumor activity of MGN-3/Biobran, a modified arabinoxylan rice bran. Swiss albino mice were inoculated intramuscularly in the right thigh with Ehrlich ascites carcinoma (EAC) cells. On…

Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast

Abstract. lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight…

Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3

Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an…

Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro

Abstract. We have recently reported that phagocytosis of killed Saccharomyces cerevisiae, baker’s yeast, induced apoptosis in human breast cancer cell lines MCF-Z, ZR- 75-1 and HCC70. In this study we have evaluated the ejfect of treatment…

Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells

Abstract. We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using…

• Saturday, 10 July 2004 8:12
  

  Experience with Administration of BioBran in Patients with Chronic Rheumatism

  Abstract: The functional food, rice bran arabinoxylan derivative (BioBran), was administered for a long period to patients with chronic rheumatism given mainly symptomatic treatments with steroids, to evaluate its supplementary effect with representative treatments for rheumatism,…Read more

• Monday, 14 June 2004 13:24
  

  Induction of Apoptosis in Breast Cancer Cells by Saccharomyces Cerevisiae, the Baker’s Yeast, In Vitro

  Abstract: The present study was undertaken to evaluate the effect of phagocytosis of killed yeast on the induction of appoptosis in human metastatic breast cancer cells (MCF-7 and ZR-75-1) and non-metastastatic breast cancer cells (HCC70). Heat-killed…Read more

• Thursday, 10 June 2004 7:30
  

  Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action

  Abstract. The preventive effect of Hydrolyzed Rice Bran against the common cold syndrome was examined in elderly people. Arabinoxylan derivatives of Hydrolyzed Rice Bran (HRB) were prepared from water-soluble rice bran through partial processing using a…Read more

• Thursday, 13 May 2004 8:21
  

  A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer

  Abstract: A patient with terminal pancreatic cancer accompanied by distant metastasis who was unfit for radical surgical treatment was subjected to treatment with the rice bran arabinoxylan derivative, which is reported to have biological defense action,…Read more

• Thursday, 13 May 2004 8:11
  

  One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy

  Abstract: A 64—year-old female patient with umbilical metastasis of recurrent colorectal cancer (SMJN) was subjected to complementary medicine using the rice bran arabinoxylan derivative), a food component of BRM activity in addition to chemotherapy in order…Read more

• Thursday, 13 May 2004 8:00
  

  Effect of Long-term Administration of lmmunomodulatory Food on Cancer Patients Completing Conventional Treatments

  Abstract: A study was conducted to investigate the effects of long-term administration of the immunomodulatory food BioBran, rice bran arabinoxylan derivative, on 16 cancer patients, mainly in stage IV with various conventional lesions, who had just…Read more

• Thursday, 13 May 2004 7:49
  

  The Clinical Significance cf BioBran in the lmmunotherapy for Cancer

  Abstract: The clinical treatments for cancer were (1) surgery, (2) radiotherapy, and (3) chemotherapy with anticancer drugs. For surgery, even if the procedure used is highly sophisticated, cancer cells may be transported to other organs via…Read more

• Thursday, 13 May 2004 7:16
  

  The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer

  The present study was designed to determine whether or not the administration of MGN-3 could have its apothanasia effect and improve the QOL for 205 progressive and partially nretastasized cancer patients in late III—IV stages after…Read more

• Monday, 10 May 2004 7:50
  

  Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

  Abstract: The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN-3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN-3…Read more

• • Saturday, 10 January 2004 8:03
    

    Augmentation of Macrophage Phagocytosis by Modified Arabinoxylan Rice Bran (MGN-3/BioBran)

    Abstract: MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however,…Read more

  • Friday, 14 November 2003 12:36
    

    Fibrinolytic and antithrombotic effect of the protein from Bacillus subtilis (natto) by the oral administration.

    Abstract: NKCP is the fragment of a part of Bacillopeptidase F from Natto bacteria (Bacillus natto), supplied as the tablet without distinct odor, bacterial cells nor vitamin K. The daily oral administration of NKCP, 28 volunteers…Read more

  • Saturday, 14 June 2003 14:10
    

    Interaction between warfarin and functional foods derived from Bacillus subtilis natto

    Abstract: Thrombotic diseases have been increasing recently and are said to account for approximately 30% of all causes of death among Japanese people. Potassium warfarin (hereinafter referred to as “wf”), a preventive for thrombosis, is the…Read more

  • Friday, 13 June 2003 9:19
    

    Modified arabinoxylan rice bran (MGN—3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis

    Abstract: MGN-3, an arabinoxylan extracted from rice bran that is treated enzymatically with an extract from Shiitaki mushrooms, is an effective biological response modifier that increases NK cell activity, and potentiates the activity of conventional chemotherapeutic…Read more

  • Monday, 13 January 2003 9:07
    

    The orally administration of the Hydrolysis Rice Bran prevents a common cold syndrome for the elderly people based on immunomodulatory function

    Abstract: The preventive effect of RIBEX against the common cold syndrome was examined on elderly people. RIBEX, containing arabinoxylan derivatives Hydrolysis Rice Bran (HRB), was prepared from the water soluble dietary fiber fraction from rice bran…Read more

  • Saturday, 14 December 2002 7:18
    

    Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozotocin as Neonates

    Abstract: The effect of modified rice bran on glucose tolerance was studied in adult non-insulin dependent diabetes mellitus (NIDDM) rats that had been caused by intraperitoneal injection of 100 mg per kg streptozotocin (STZ) at 1….Read more

  • Friday, 13 December 2002 9:33
    

    Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin

    Abstract: Alkylating agents and antimetabolites remain prominent in a wide variety of cancer chemotherapy protocols on the basis of more selective effects on the faster than normal mitotic cycles of malignant cells. Among new platinum—containing anticancer…Read more

  • Thursday, 14 June 2001 7:51
    

    The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence

    Abstract: Arabinoxylan (hereafter called MGN-3) is a plant polysaccharide processed food with a biophylactic action, which mainly contains polysaccharides such as hemicellulose and arabinoxylan and glycoprotein. MGN-3 is known to have various biophylactic actions such as in…Read more

  • Thursday, 14 June 2001 7:34
    

    The Effect of MGN-3 on Cisplatin and Doxorubicin Induced Toxicity in the Rat

    Abstract:  MGN-3 (BioBran) is derived from rice bran and is produced by the partial hydrolysis of the water soluble hemicellulose fraction of rice bran by carbohydrases derived from Lentius eclarles mycelia.It is a biological response modifier…Read more

  • • Wednesday, 14 June 2000 9:12
      

      NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran (Study of 32 Patients Followed for up to 4 Years)

      Abstract: NK cells have been characterized as non-B cells or non-T cells lacking the characteristics of mature macrophages which develop from the bone marrow independently of thymic influence. NK cells play a crucial role in tumor…Read more

    • Wednesday, 14 June 2000 8:47
      

      Production of Tumor Necrosis Factor-α and Interferon-γ from Human Peripheral Blood Lymphocytes by MGN-3, a Modified Arabinoxylan from Rice Bran, and Its Synergy with Interleukin-2 In Vitro

      Abstract:  Recently, we presented evidence for the role of MGN-3, an enzymatically modified arabinoxylan extracted from rice bran, in potent activation of human natural killer (NK) cell function in vivo and in vitro. In the current…Read more

    • Wednesday, 14 June 2000 8:25
      

      Scavenging Activity 0f MGN-3 (Arabinoxylane from Rice Bran) with Natural Killer Cell Activity On Free Radicals

      Abstract: MGN-3, which produces a remarkable increase in natural killer cell activity, showed a high scavenging rate on hypoxanthine-xanthine oxidase generated superoxide anion radicals, and on ferrous sulfate-hydrogen peroxide and UV light reaction system generated hydroxyl radicals….Read more

    • Wednesday, 14 June 2000 8:03
      

      Effects of Modified Rice Bran on Serum Lipids and taste preference in Streptozotocin-induced Diabetic Rats

      Abstract: The present study was designed to determine whether or not the administration of modified rice bran could improve streptozotocin (STZ)-induced diabetes. Taste preferences were also compared in diabetic and control rats. Male Sprague-Dawley rats were…Read more

    • Sunday, 14 June 1998 9:49
      

      Enhancement of Human Natural Killer Cell Activity by Modified Arabinoxylane From Rice Bran (MGN-3)

      Abstract: Arabinoxylane from rice bran (MGN-3) was examined for its augmentory effect on human NK (NK) cell activity in vivo and in vitro. Twenty-four individuals were given MGN-3 orally at three different concentrations: 15, 30 and…Read more

    • Saturday, 14 June 1997 9:32
      

      Anti-HIV Activity in Vitro of MGN-3, an Activated Arabinoxylane from Rice Bran

      Abstract: MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from Hyphomycetes mycelia, was tested for anti-HIV activity in vitro. MGN-3 activity against HIV -1 (SF strain) was examined in primary cultures…Read more