Badania kliniczne

Strona Główna / Badania kliniczne

Thursday, 18 April 2024 13:30

Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects

Abstract:  Corona Virus Disease 19 (COVID-19) has been a major pandemic impacting a huge population worldwide, and it continues to present serious health threats, necessitating the development of novel protective nutraceuticals. Biobran/MGN-3, an arabinoxylan rice bran, is a potent immunomodulator…Read more


Wednesday, 20 August 2014 12:01

Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study

Abstract:  Background. Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance ofthe lower digestive tract is one of the mechanisms involved in symptom generation in patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan…Read more


Tuesday, 10 June 2014 11:34

Modified Arabinoxylan from Rice Bran, MGN-3/Biobran, Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitr

Abstract: Background: There is an increased interest in alternative treatments that reduce the toxicity of chemotherapy by lowering the drug concentration, whilst maintaining potency against cancer cells. Previous studies have demonstrated that arabinoxylan from rice bran,…Read more


Thursday, 17 April 2014 7:12

Protective effect of low molecular fraction of MGN—3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF— κB and JNK/MAPK expression

Abstract: D-Galactosamine (GaIN) induces acute hepatitis in experimental animals; this hepatitis has been shown to be suppressed by oral or intraperitoneal administration of modified arabinoxylan from rice bran (MGN—3), and active low molecular fraction isolated from…Read more


Thursday, 17 April 2014 6:27

Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body ƴ-irradiation in mice via restoration of hematopoietic tissues

Abstract:  The aim of the current study is to examine the protective effect of MGN-3 on overall maintenance of hematopoietic tissue after ƴ-irradiation. MGN-3 is an arabinoxylan from rice bran that has been shown to be…


Tuesday, 19 February 2013 8:04

Case Reports of Cancer Patients with Hepatic Metastases Treated by Standardized Plant lmmunomodulatory Preparations

Abstract: Background: Metastatic hepatocellular carcinoma often has a multifocal tumor pattern with markedly depressed hepatic function, Hepatic resection in many cases results in no long-term benefit. After a chemotherapy hepatic tumors rarely disappear completely and the duration…Read more


Sunday, 14 October 2012 21:32

An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults

Rice Bran Arabinoxylan Compound (RBAC) is a nutritional supplement produced by enzymatic hydrolysis of hemicellulose B derived from rice bran. Several in vitro studies and clinical reports have shown RBAC to possess promising immunomodulating effects, specifically…Read more


Friday, 07 September 2012 6:43

Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats

Abstract: We investigated in this study the effect of modified arabinoxylan from rice bran (MGN-3) and its fractions on D-galactosamine (D-GalN)-induced IL-18 expression and hepatitis in rats. Male Wistar rats were pretreated with MGN-3 or fractions…Read more


Wednesday, 25 July 2012 6:23

Synergistic apoptotic effect of Arabinoxylan rice bran (MGN-3/Biobran) and Curcumin (Turmeric) on human multiple myeloma cell line U266 in vitro

Abstract: The present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266 , in vitro. U266 cells were cultured…Read more


Friday, 10 February 2012 9:48

Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier Arabinoxylan rice bran (MGN-3/BioBran)

Abstract: Arabinoxylan rice bran (MGN—3/Biobran) is a potent biological response modifier (BRM) that activates natural killer (NK) cells, T cells and monocytes. Currently, little is known regarding the effects of MGN-3 on dendritic cells (DCs), the…Read more


Monday, 19 December 2011 2:40

The clinical effectiveness of BioBran in immunotherapy for patients with hepatitis B

BioBran is a food supplement that is combined with conventional treatment to improve the outcome of the disease. There were 3 cases of viral B hepatitis patients who have treated by the combination of conventional antiviral…Read more


Friday, 30 September 2011 8:09

Maternal-fetal distribution and transfer of dioxins in pregnant Women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements

Abstract: Dioxins can be transferred from mother to fetus via the placenta, or to nursing infants via breast milk, potentially causing developmental health problems in children. To assess pediatric health risks from dioxins, exposure of mothers…Read more


Friday, 01 October 2010 7:53

Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial

Abstract. Background and Aims: This study examined the efficacy of arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy (IT) for the treatment of hepatocellular carcinoma patients. Patients and Methods: A total of sixty-eight patients…Read more


Sunday, 07 June 2009 8:15

Epigenetics and Immurmsenescence Reversal: An Evidence-Based Longevity Paradigm

Abstract: Humankind has long thought of aging as a gradual, time—dependent, deterioration in one‘s well-being and quality of life, with an increased incidence and severity of debilitating chronic diseases. However, current medical opinion argues for a…Read more


Wednesday, 17 September 2008 8:48

BioBran – augmented maturation of human monocyte – derived dendritic cells

Abstract: BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro matumtion of human dendritic cells (DC). lmmature DC (iDC) derived from plastic-adhered, lL-4 and GM-CSF treated peripheral monocytes (Mo).. Read more


Monday, 11 February 2008 7:32

MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunombicin.

Abstract: Background: MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi..

Read more


Tuesday, 23 October 2007 9:15

Modified Arabinoxylan Rice Bran (MGN-3/BioBran) enhances Intracellular killing of microbes by human Phagocytic cells In Vitro

Abstract: Phagocytic cells, comprised of neutrophils and moncytyes/macrophages, play a key role in the innate immune response to infection. Our earlier study demonstrated that arabinoxylan rice bran (MGN-3/Biobran) activates murine peritoneal macrophage and macrophage cell lines…

Read more


Friday, 08 June 2007 7:56

Yeast therapy for the treatment of cancer and its enhancement by MGN-3/BioBran, an Arabinoxylan rice bran

Abstract: Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative…Read more


Monday, 07 May 2007 9:40

In Vivo Tumor lnhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice.

Abstract: This study was undertaken to investigate the in vivo anti-tumor activity of MGN-3/Biobran, a modified arabinoxylan rice bran. Swiss albino mice were inoculated intramuscularly in the right thigh with Ehrlich ascites carcinoma (EAC) cells. On…

Read more



Thursday, 08 June 2006 9:06

Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast

Abstract. lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight…Read more


Thursday, 08 June 2006 8:29

Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3

Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an…Read more



Friday, 10 June 2005 7:13

Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro

Abstract. We have recently reported that phagocytosis of killed Saccharomyces cerevisiae, baker’s yeast, induced apoptosis in human breast cancer cell lines MCF-Z, ZR- 75-1 and HCC70. In this study we have evaluated the ejfect of treatment…Read more


Wednesday, 08 June 2005 9:38

Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells

Abstract. We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using…Read more


Saturday, 10 July 2004 8:12

Experience with Administration of BioBran in Patients with Chronic Rheumatism

Abstract: The functional food, rice bran arabinoxylan derivative (BioBran), was administered for a long period to patients with chronic rheumatism given mainly symptomatic treatments with steroids, to evaluate its supplementary effect with representative treatments for rheumatism,…Read more


Monday, 14 June 2004 13:24

Induction of Apoptosis in Breast Cancer Cells by Saccharomyces Cerevisiae, the Baker’s Yeast, In Vitro

Abstract: The present study was undertaken to evaluate the effect of phagocytosis of killed yeast on the induction of appoptosis in human metastatic breast cancer cells (MCF-7 and ZR-75-1) and non-metastastatic breast cancer cells (HCC70). Heat-killed…Read more


Thursday, 10 June 2004 7:30

Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action

Abstract. The preventive effect of Hydrolyzed Rice Bran against the common cold syndrome was examined in elderly people. Arabinoxylan derivatives of Hydrolyzed Rice Bran (HRB) were prepared from water-soluble rice bran through partial processing using a…Read more


Thursday, 13 May 2004 8:21

A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer

Abstract: A patient with terminal pancreatic cancer accompanied by distant metastasis who was unfit for radical surgical treatment was subjected to treatment with the rice bran arabinoxylan derivative, which is reported to have biological defense action,…Read more


Thursday, 13 May 2004 8:11

One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy

Abstract: A 64—year-old female patient with umbilical metastasis of recurrent colorectal cancer (SMJN) was subjected to complementary medicine using the rice bran arabinoxylan derivative), a food component of BRM activity in addition to chemotherapy in order…Read more


Thursday, 13 May 2004 8:00

Effect of Long-term Administration of lmmunomodulatory Food on Cancer Patients Completing Conventional Treatments

Abstract: A study was conducted to investigate the effects of long-term administration of the immunomodulatory food BioBran, rice bran arabinoxylan derivative, on 16 cancer patients, mainly in stage IV with various conventional lesions, who had just…Read more


Thursday, 13 May 2004 7:49

The Clinical Significance cf BioBran in the lmmunotherapy for Cancer

Abstract: The clinical treatments for cancer were (1) surgery, (2) radiotherapy, and (3) chemotherapy with anticancer drugs. For surgery, even if the procedure used is highly sophisticated, cancer cells may be transported to other organs via…Read more


Thursday, 13 May 2004 7:16

The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer

The present study was designed to determine whether or not the administration of MGN-3 could have its apothanasia effect and improve the QOL for 205 progressive and partially nretastasized cancer patients in late III—IV stages after…Read more


Monday, 10 May 2004 7:50

Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

Abstract: The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN-3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN-3…Read more


Saturday, 10 January 2004 8:03

Augmentation of Macrophage Phagocytosis by Modified Arabinoxylan Rice Bran (MGN-3/BioBran)

Abstract: MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however,…Read more


Friday, 14 November 2003 12:36

Fibrinolytic and antithrombotic effect of the protein from Bacillus subtilis (natto) by the oral administration.

Abstract: NKCP is the fragment of a part of Bacillopeptidase F from Natto bacteria (Bacillus natto), supplied as the tablet without distinct odor, bacterial cells nor vitamin K. The daily oral administration of NKCP, 28 volunteers…Read more


Saturday, 14 June 2003 14:10

Interaction between warfarin and functional foods derived from Bacillus subtilis natto

Abstract: Thrombotic diseases have been increasing recently and are said to account for approximately 30% of all causes of death among Japanese people. Potassium warfarin (hereinafter referred to as “wf”), a preventive for thrombosis, is the…Read more


Friday, 13 June 2003 9:19

Modified arabinoxylan rice bran (MGN—3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis

Abstract: MGN-3, an arabinoxylan extracted from rice bran that is treated enzymatically with an extract from Shiitaki mushrooms, is an effective biological response modifier that increases NK cell activity, and potentiates the activity of conventional chemotherapeutic…Read more


Monday, 13 January 2003 9:07

The orally administration of the Hydrolysis Rice Bran prevents a common cold syndrome for the elderly people based on immunomodulatory function

Abstract: The preventive effect of RIBEX against the common cold syndrome was examined on elderly people. RIBEX, containing arabinoxylan derivatives Hydrolysis Rice Bran (HRB), was prepared from the water soluble dietary fiber fraction from rice bran…Read more


Saturday, 14 December 2002 7:18

Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozotocin as Neonates

Abstract: The effect of modified rice bran on glucose tolerance was studied in adult non-insulin dependent diabetes mellitus (NIDDM) rats that had been caused by intraperitoneal injection of 100 mg per kg streptozotocin (STZ) at 1….Read more


Friday, 13 December 2002 9:33

Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin

Abstract: Alkylating agents and antimetabolites remain prominent in a wide variety of cancer chemotherapy protocols on the basis of more selective effects on the faster than normal mitotic cycles of malignant cells. Among new platinum—containing anticancer…Read more


Thursday, 14 June 2001 7:51

The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence

Abstract: Arabinoxylan (hereafter called MGN-3) is a plant polysaccharide processed food with a biophylactic action, which mainly contains polysaccharides such as hemicellulose and arabinoxylan and glycoprotein. MGN-3 is known to have various biophylactic actions such as in…Read more


Thursday, 14 June 2001 7:34

The Effect of MGN-3 on Cisplatin and Doxorubicin Induced Toxicity in the Rat

Abstract:  MGN-3 (BioBran) is derived from rice bran and is produced by the partial hydrolysis of the water soluble hemicellulose fraction of rice bran by carbohydrases derived from Lentius eclarles mycelia.It is a biological response modifier…Read more


Wednesday, 14 June 2000 9:12

NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran (Study of 32 Patients Followed for up to 4 Years)

Abstract: NK cells have been characterized as non-B cells or non-T cells lacking the characteristics of mature macrophages which develop from the bone marrow independently of thymic influence. NK cells play a crucial role in tumor…Read more


Wednesday, 14 June 2000 8:47

Production of Tumor Necrosis Factor-α and Interferon-γ from Human Peripheral Blood Lymphocytes by MGN-3, a Modified Arabinoxylan from Rice Bran, and Its Synergy with Interleukin-2 In Vitro

Abstract:  Recently, we presented evidence for the role of MGN-3, an enzymatically modified arabinoxylan extracted from rice bran, in potent activation of human natural killer (NK) cell function in vivo and in vitro. In the current…Read more


Wednesday, 14 June 2000 8:25

Scavenging Activity 0f MGN-3 (Arabinoxylane from Rice Bran) with Natural Killer Cell Activity On Free Radicals

Abstract: MGN-3, which produces a remarkable increase in natural killer cell activity, showed a high scavenging rate on hypoxanthine-xanthine oxidase generated superoxide anion radicals, and on ferrous sulfate-hydrogen peroxide and UV light reaction system generated hydroxyl radicals….Read more


Wednesday, 14 June 2000 8:03

Effects of Modified Rice Bran on Serum Lipids and taste preference in Streptozotocin-induced Diabetic Rats

Abstract: The present study was designed to determine whether or not the administration of modified rice bran could improve streptozotocin (STZ)-induced diabetes. Taste preferences were also compared in diabetic and control rats. Male Sprague-Dawley rats were…Read more


Sunday, 14 June 1998 9:49

Enhancement of Human Natural Killer Cell Activity by Modified Arabinoxylane From Rice Bran (MGN-3)

Abstract: Arabinoxylane from rice bran (MGN-3) was examined for its augmentory effect on human NK (NK) cell activity in vivo and in vitro. Twenty-four individuals were given MGN-3 orally at three different concentrations: 15, 30 and…Read more


Saturday, 14 June 1997 9:32

Anti-HIV Activity in Vitro of MGN-3, an Activated Arabinoxylane from Rice Bran

Abstract: MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from Hyphomycetes mycelia, was tested for anti-HIV activity in vitro. MGN-3 activity against HIV -1 (SF strain) was examined in primary cultures…Read more


Napisz do nas

Jeśli masz jakiekolwiek pytania, możesz skorzystać z formularza kontaktowego i napisz do nas.

Nie czytelne? Zmień tekst. captcha txt

Zacznij pisać a następnie naciśnij klawisz Enter aby wyszukać